I have a tooth that is killing. I am going to have wait until morning to call a dentist to see if I can get and get something done about the tooth. A home remedy for a toothache is take an aspirin and place it on the tooth in question. Than hold the aspirin on the tooth with your tongue until it melts into the tooth to help relieve the pain. I have used both Tylenol Extra Stength and Excedrin for this. In this video I am holding RIte AIde generic version of Tylenol Extra Stength.